Anna Orlova Selected Research

Bombesin Receptors (Bombesin Receptor)

11/2021	66Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66Ga]Ga-NOTA-PEG2-RM26.
1/2021	Preclinical Evaluation of 99mTc-Labeled GRPR Antagonists maSSS/SES-PEG2-RM26 for Imaging of Prostate Cancer.
12/2020	Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer.
7/2020	Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model.
1/2020	Radiolabeled GRPR Antagonists for Imaging of Disseminated Prostate Cancer - Influence of Labeling Chemistry on Targeting Properties.
12/2019	Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177 Lu-DOTAGA-PEG2 -RM26.
11/2019	Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26.
9/2019	Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer.
8/2019	Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart.
7/2019	Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer.

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Anna Orlova Research Topics

Disease

156	Neoplasms (Cancer) 05/2022 - 08/2003
27	Prostatic Neoplasms (Prostate Cancer) 05/2022 - 04/2011
19	Breast Neoplasms (Breast Cancer) 01/2022 - 08/2004
13	Carcinoma (Carcinomatosis) 05/2020 - 11/2004
12	Neoplasm Metastasis (Metastasis) 10/2019 - 11/2004
5	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 08/2003
4	Ovarian Neoplasms (Ovarian Cancer) 05/2022 - 06/2006
4	Glioma (Gliomas) 01/2018 - 08/2003
3	Inflammation (Inflammations) 12/2019 - 01/2014
3	Colorectal Neoplasms (Colorectal Cancer) 01/2014 - 10/2005
2	Disease Progression 01/2021 - 06/2019
2	Renal Cell Carcinoma (Grawitz Tumor) 10/2019 - 11/2016
2	Squamous Cell Carcinoma of Head and Neck 04/2016 - 11/2004
2	Neoplasm Micrometastasis 09/2009 - 10/2005
1	type 1 Stickler syndrome 01/2022
1	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 01/2022
1	Kniest dysplasia 01/2022
1	Triple Negative Breast Neoplasms 10/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 06/2020
1	Lymphoma (Lymphomas) 05/2020
1	Adenocarcinoma 02/2020
1	Virus Diseases (Viral Diseases) 12/2019
1	Infections 12/2019

Drug/Important Bio-Agent (IBA)

58	Radioisotopes (Radionuclides)IBA 05/2022 - 04/2004
29	ErbB Receptors (EGF Receptor)IBA 05/2022 - 08/2004
24	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 10/2020 - 02/2007
23	Proteins (Proteins, Gene)FDA Link 11/2021 - 04/2006
16	Bombesin Receptors (Bombesin Receptor)IBA 11/2021 - 01/2013
15	Trastuzumab (Herceptin)FDA Link 01/2022 - 08/2005
15	Chelating AgentsIBA 03/2020 - 02/2007
13	Pharmaceutical PreparationsIBA 05/2022 - 10/2007
13	Monoclonal AntibodiesIBA 01/2022 - 11/2004
12	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA 11/2021 - 05/2011
10	AntigensIBA 05/2022 - 10/2005
10	human ERBB2 proteinIBA 01/2022 - 06/2010
10	1- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA 12/2020 - 03/2012
9	Epidermal Growth Factor (EGF)IBA 01/2021 - 08/2003
8	Cys-ZHER2-342 affibodyIBA 01/2018 - 02/2007
7	Designed Ankyrin Repeat ProteinsIBA 01/2022 - 01/2018
7	BombesinIBA 01/2020 - 01/2013
6	AlbuminsIBA 02/2022 - 01/2018
6	Tyrosine Kinase InhibitorsIBA 01/2021 - 11/2014
6	Peptides (Polypeptides)IBA 10/2020 - 01/2013
6	AntibodiesIBA 06/2020 - 08/2003
6	Pentetic Acid (DTPA)FDA LinkGeneric 10/2019 - 08/2003
6	AndrogensIBA 07/2014 - 04/2011
5	Epithelial Cell Adhesion MoleculeIBA 08/2021 - 02/2020
5	Indium-111IBA 07/2021 - 04/2007
5	LigandsIBA 06/2020 - 04/2006
3	Immunoconjugates (Immunoconjugate)IBA 05/2022 - 01/2018
3	Photosensitizing Agents (Photosensitizers)IBA 12/2021 - 07/2010
3	seribantumabIBA 09/2021 - 01/2018
3	Hormones (Hormone)IBA 01/2019 - 04/2011
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 07/2010
3	Peptide Nucleic AcidsIBA 01/2018 - 01/2016
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2017 - 03/2009
3	ABY-025IBA 01/2016 - 05/2011
3	Cysteine (L-Cysteine)FDA Link 04/2015 - 03/2007
2	Oxygen (Dioxygen)IBA 01/2022 - 02/2017
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 12/2021 - 02/2021
2	Aligeron (AS 2)IBA 01/2021 - 06/2010
2	EnzymesIBA 01/2020 - 11/2016
2	Transcription Factors (Transcription Factor)IBA 12/2019 - 02/2019
2	CobaltIBA 11/2019 - 01/2017
2	Carbonic Anhydrase IXIBA 10/2019 - 11/2016
2	Cetuximab (Erbitux)FDA Link 01/2019 - 04/2011
2	Immunoglobulins (Immunoglobulin)IBA 01/2018 - 01/2016
2	Technetium (Technetium 99m)IBA 01/2018 - 03/2006
2	Phosphotransferases (Kinase)IBA 01/2018 - 10/2010
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 04/2016 - 04/2011
2	Oncogene Proteins (Oncogene Protein)IBA 10/2015 - 06/2006
2	IndiumIBA 06/2014 - 11/2007
2	IodineIBA 06/2014 - 03/2006
2	IsotopesIBA 07/2013 - 11/2004
2	RadiopharmaceuticalsIBA 03/2011 - 03/2007
2	benzyl-DTPAIBA 09/2007 - 08/2003
2	Benzoates (Benzoate)IBA 07/2006 - 11/2004
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2022
1	Liposomes (Liposome)IBA 12/2021
1	EpitopesIBA 11/2021
1	Gallium-66IBA 11/2021
1	chlorinIBA 02/2021
1	glycylhistidineIBA 01/2021
1	Cobalt-55IBA 12/2020
1	Copper-64IBA 12/2020
1	Human Serum Albumin FDA LinkGeneric 10/2020
1	Blood Proteins (Serum Proteins)IBA 01/2020
1	Antiviral Agents (Antivirals)IBA 12/2019
1	Interferon Type IIBA 12/2019
1	RNA (Ribonucleic Acid)IBA 12/2019

Therapy/Procedure

78	Therapeutics 05/2022 - 08/2004
7	Gamma Cameras (Gamma Camera) 11/2014 - 04/2006
3	Precision Medicine 12/2021 - 10/2015
2	Radiotherapy 01/2022 - 12/2019
2	Immunotherapy 01/2018 - 01/2014
2	Radioimmunotherapy 06/2013 - 10/2005
1	Drug Therapy (Chemotherapy) 12/2021
1	Cyclotrons 11/2021
1	Intravenous Administration 02/2021
1	Investigational Therapies (Experimental Therapy) 12/2020